VALIDATION OF THE NEW EPIC DNA METHYLATION MICROARRAY (900K EPIC V2) FOR HIGH-THROUGHPUT PROFILING OF THE HUMAN DNA METHYLOME

Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome

DNA methylation, one of the best characterized epigenetic marks in the human genome, plays a pivotal role in gene transcription regulation and other biological processes in humans.On top of that, the DNA methylome undergoes profound changes in cancer and other disorders.However, large-scale and population-based studies are limited by high costs and

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Prevalence of substandard, falsified, unlicensed and unregistered medicine and its associated factors in Africa: a systematic review

Background: Substandard, falsified, unlicensed, and unregistered medicines pose significant risks to public health in developed and developing countries.This systematic review provides an overview of the prevalence of substandard, falsified, unlicensed, and unregistered medicine and its associated factors in Africa.Methods: Articles published from

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A genetic analysis of retinitis pigmentosa

The data consists of sixty probands affected with Retinitis pigmentosa.Syndromic cases were found in read more five percent of the RP probands.Segregation analysis was carried out on proband sibship data.The ascertainment probability was estimated at 0.5517.Analysis of the data by parental mating types of proband sibships indicated the presence of

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On Rigorous Drought Assessment Using Daily Time Scale: Non-Stationary Frequency Analyses, Revisited Concepts, and a New Method to Yield Non-Parametric Indices

Some of the problems in drought assessments are that: analyses tend to focus on coarse temporal scales, many of the methods yield skewed indices, a few terminologies are ambiguously used, and analyses comprise an implicit assumption that the observations come from a stationary process.To solve these problems, this paper introduces non-stationary fr

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